Local Delivery of Ox40l, Cd80, and Cd86 mRNA Kindles Global Anticancer Immunity
نویسندگان
چکیده
منابع مشابه
CD80/CD86 costimulation regulates acute vascular rejection.
Xenotransplantation may provide the only solution to the shortage of human donor organs. Although hyperacute rejection associated with xenotransplantation can now be overcome, acute vascular rejection (AVR) remains a primary barrier to xenotransplantation. To date, standard immunosuppressive agents fail to block AVR or prolong xenograft survival. The present study was undertaken to determine th...
متن کاملCD80 and CD86 expression on LPS-stimulated monocytes and the effect of CD80 and CD86 blockade on IL-4 and IFN-gamma production in nonatopic bronchial asthma.
CD80 and CD86 seem to play an important role in the allergen-induced secretion of interleukin (IL)-5 and IL-13. Up to now, the expressions of CD80 (B7.1) and CD86 (B7.2) on monocytes and the kinetics of the expression of these molecules on lipopolysaccharide-stimulated monocytes in nonatopic asthma have not been defined. Using monoclonal antibodies, we have compared the expressions of CD80 (B7....
متن کاملDifferential requirement for CD80 and CD80/CD86-dependent costimulation in the lung immune response to an influenza virus infection.
The CD28 costimulatory pathway is critical to T cell activation. Blockade of the interaction of CD28 with its ligands CD80 and CD86 using CTLA4-Ig has been proposed as a therapy for a number of immune-based disorders. We have used a murine model of influenza virus infection to study the role of CD28-dependent costimulation in the development of antiviral immune responses. In vivo treatment with...
متن کاملExpression of CD80 and CD86 on T lymphocytes and monocytes of asthmatic children
INTRODUCTION The concept of costimulation has changed the way of understanding how T cells recognise and respond to antigens . The current model of T cell activation requires two signals: Signal 1: It is only an initiation event. It requires T cell receptor recognition and binding to antigen presented by antigen presenting cells. However this signal alone is necessary but not sufficient to indu...
متن کاملCritical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation.
Intraocular inoculation of antigens induces anterior chamber-associated immune deviation (ACAID), which is mediated by development of regulatory T cells in response to antigen-presenting cells (APC) pre-conditioned by intraocular transforming growth factor-beta (TGF-beta). In this study, we examined the involvement of T-cell co-stimulatory molecules in this process. To mimic the intraocular APC...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2019
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-18-2867